Pirfenidone CAS NO.53179-13-8

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Product Details

Keywords

Pyridon
53179-13-8
Pirfenidone

Quick Details

ProName: Pirfenidone
CasNo: 53179-13-8
Molecular Formula: C12H11NO
Appearance: White powder
Application: The product is used as chemical reagen...
DeliveryTime: In stock
PackAge: 25kg/ drum 1kg/bag or 10mg/ drum
Port: ShangHai
ProductionCapacity: 2000 Metric Ton/Month
Purity: 99%
Storage: Store in cool, dry, Storage Temp: 2-8°...
Transportation: Store in cool, dry, Storage Temp: 2-8°...
LimitNum: 1 Gram
Moisture Content: ≤1.0%
Impurity: ≤1.0%

Superiority

Union Pharmpro Co., Ltd is in business of raw materials of health industrial for nearly 14

years. Union Pharmpro is now a united group of three companies( Watson Industries, Yasen

Biological Technology co., Ltd),with it’s headquarters in China and USA is dedicated to the

production and distribution of ingredients to the food,dietary supplement,sports supplement,

cosmetic, pharmaceutical and veterinary industries.

Details

Product:Name:Pirfenidone

Synonyms:5-Methyl-1-phenyl-2-(1H)-pyridone; 5-methyl-1-phenylpyridin-2(1H)-one

Molecular Formula:C12H11NO

Molecular Weight:185.2218

InChI:InChI=/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3

CAS Registry Number:53179-13-8

Density1.138g/cm3:

Boiling point:329.075°C at 760 mmHg

Refractive index:1.592

Flash point:152.741°C

Vapour Pressure:0mmHg at 25°C

In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation.

Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation.

Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation.

In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin.

Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice.

Pirfenidone 0.01 1mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also.

Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

Quality Control System

We do strict quality control in whole production process. All unqualified products are rejecting before shipping.